protein production prevents sleep-loss forgetfulness - best glass water bottle with silicone sleeve
Losing sleep can damage the brain's ability to remember.
New research in mice shows that protein is constructed.
Improving the protein production of a learning and memory center in the brain can eliminate the forgetting caused by lack of sleep. on November 17, Jennifer Tudor, a neuroscientist at the University of Pennsylvania, was at the annual meeting of the Neuroscience Society.
Tudor and her colleagues have been trying to identify molecular fingerprints left on the hippocampus with insufficient sleep.
Form and consolidate the brain structure of memory.
In the past, the mice stayed up late to change the activity of more than 500 genes.
Some of these genes are related to proteins.
It is called the construction process of translation.
Decreased overall protein production during sleep
Deprived mice compared to well-rested ones.
Among these plunging proteins, some are involved in a network of communications within the cell, the so-called mammal pathway.
The pathway controls various processes, including cell growth, survival, movement, gene activity, protein production, and self-type
Called the recycling process of autophagy.
Disruption of the system can lead to cancer and other diseases.
Tudor and his colleagues raised the level of target protein pathway proteins called 4E binding protein 2 (4EBP2) in the hippocampus of some mice.
Typically, 4EBP2 locks the molecules needed for translation and shuts down the translation process.
When cells get a signal that they need more protein
What may happen when building memory-
The target protein and companion protein attach the phosphate to 4EBP2 to separate it from the molecule, thus allowing protein production to continue.
In the experiment, the researchers raised 4EBP2 above the normal level.
Content of phosphate
Although Tudor does not yet know what is responsible for the phosphate, the form of fullness has also risen.
The researchers found that the production of more 4EBP2 phosphate forms can allow hippocampus cells to produce more protein.
See if protein can be fixed.
The researchers performed memory tests on mice, and production problems also fixed memory defects.
The mouse is placed in a cage with three objects: a metal tower, a glass bottle and a plastic syringe.
Tudor and colleagues mild to deal with the some mouse let they in normal sleep before keep five a hours.
The others slept all night.
The next day, the researchers put the mouse back in the cage with three objects, but this time, one of the items was in a different position. Well-
Resting rodents spend more time sniffing and exploring displaced objects than undisturbed rodents. Sleep-
The time spent by deprived mice playing with each item was roughly equal, indicating that they did not remember the previous location and did not know that one item was moved. Sleep-
Deprived mice that produce more 4EBP2 in the hippocampus remember these objects and respond similarly well to displaced objectsrested mice.
Jonathan Lipton, a time biologist and sleep neurologist at Boston Children's Hospital and Harvard Medical School, said it was an interesting idea to offset the shortcomings of lack of sleep. But such broad-
Mass patching of tor systems may not be a viable approach due to many possible negative effects.
Next, the researchers will determine which specific proteins must be manufactured to form memories, he said.